Drug Discov Ther. 2015;9(1):75-77. (DOI: 10.5582/ddt.2015.01005)

Combination chemotherapy with S-1 and docetaxel for cutaneous angiosarcoma resistant to paclitaxel.

Kajihara I, Kanemaru H, Miyake T, Aoi J, Masuguchi S, Fukushima S, Jinnin M, Ihn H

The prognosis of cutaneous angiosarcoma is very poor compared with that of other skin malignancies. The main reason for this is the limited regimens of chemotherapy available for angiosarcoma, because it is resistant to most common chemotherapeutic agents. Therefore, there is an urgent need to identify new treatment options. Recently, S-1 and docetaxel therapy was reported to be effective for advanced gastric cancer and metastatic extramammary Paget's disease. Therefore, we treated paclitaxel-resistant angiosarcoma patient with S-1/docetaxel chemotherapy. The progression-free survival was 5.0 months although grade 3 adverse events such as diarrhea and neutropenia developed. Our data need to be confirmed in a large number of patients, but S-1/docetaxel chemotherapy as an additional regimen seems to be an effective treatment option for paclitaxel-resistant angiosarcoma.

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