Drug Discov Ther. 2017;11(2):115-117. (DOI: 10.5582/ddt.2016.01082)

Levetiracetam and topiramate poisoning: Two overdoses on those drugs with no lasting effects.

Sarfaraz M, Hasan SR


Levetiracetam and topiramate are newer anticonvulsants, which is why international data on overdoses of these drugs are lacking. Only a few mild adverse reactions have been noted. These anticonvulsants have been the drug of choice for neurologists. Despite their wide usage, there is a dearth of literature on symptoms and signs of their toxicity. Presented here is the case of a 21-year-old female who overdosed twice on levetiracetam and topiramate. The woman was admitted and discharged after the first overdose. Ten days later, she took multiple tablets of both drugs and was seen again. Amazingly, the woman went home after the incident with no complications at all.

KEYWORDS: Anticonvulsants, toxicity, seizures, gastrointestinal decontamination, activated charcoal

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