Drug Discov Ther. 2008;2(4):216-218.

Synthesis and antifungal activity of 3-substituted thiochromanones.

Liu Y, Luo W, Sun L, Guo C


A series of 3-substituted thiochromanones has been prepared. Their structures were confirmed by H1-NMR and HRMS. All of the synthesized compounds were screened for antifungal activity against ten fungi species in vitro. The compounds 2f and 2g were more efficient than the control drug, ketoconazole.

KEYWORDS: Thiochromanone, Synthesis, Antifungal activity

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