Drug Discov Ther. 2018;12(3):154-160. (DOI: 10.5582/ddt.2018.01007)

Clinical effect of long-term administration of tolvaptan in patients with heart failure and chronic kidney disease.

Ono Y, Takamatsu H, Inoue M, Mabuchi Y, Ueda T, Suzuki T, Kurabayashi M

The effectiveness of long-term administration of tolvaptan in heart failure (HF) patients with chronic kidney disease (CKD) has not been fully studied. Hence, in this study, we investigated the effects of chronic administration of tolvaptan on patients with HF and CKD. We consecutively enrolled 31 patients with acute HF syndrome (AHFS) who were administrated tolvaptan as a long-term medication (TLV group). All patients had a history of prior HF admission and CKD. We also consecutively enrolled 27 patients with AHFS, a prior history of HF and CKD (conventional group). We compared renal function and outcomes between the two groups at discharge for AHFS and after 6 months of followup. The estimate glomerular filtration rate (eGFR) was maintained at approximately the same level in the TLV group exhibited approximately the same eGFR (–1.1 ± 8.3 mL/min/1.73 m²) but decreased in the conventional group (–7.4 ± 10.4 mL/min/1.73 m²). There was a significant difference in the changes observed in eGFR between the conventional and TLV groups (p = 0.01). There were no significant differences in the frequencies of rehospitalization and death. Long-term administration of tolvaptan may prevent increased renal dysfunction in HF patients with CKD. This conclusion should be confirmed in a largescale prospective study.

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