Drug Discov Ther. 2019;13(5):244-247. (DOI: 10.5582/ddt.2019.01069)

Suppressive effects of whey protein hydrolysate on sucrose-induced hyperglycemia in silkworms.

Matsumoto Y, Takahashi M, Umehara M, Asano M, Maruki-Uchida H, Morita M, Sekimizu K


Silkworms are useful for evaluating substances that suppress postprandial hyperglycemia by oral administration. In this study, orally administered whey protein hydrolysate (WPH), obtained by enzymatic treatment of whey protein, suppressed sucrose-induced hyperglycemia in silkworms in a dose-dependent manner. WPH also inhibited glucose-induced hyperglycemia in silkworms. These findings suggest that WPH contains a bioactive peptide that inhibits glucose uptake from the intestinal tract and thereby suppresses sucrose-induced hyperglycemia.

KEYWORDS: Hyperglycemia, silkworm, sucrose, whey protein hydrolysate

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