Drug Discov Ther. 2021;15(2):112-117. (DOI: 10.5582/ddt.2021.01033)

Focal nodular hyperplasia mimicking hepatocellular adenoma and carcinoma in two cases

Zhu M, Li H, Wang C, Yang B, Wang X, Hou F, Yang S, Wang Y, Guo X, Qi X


Focal nodular hyperplasia (FNH) is a solid benign tumor of the liver, predominantly in young women. A correct diagnosis of FNH is essential for making appropriate clinical decisions and avoiding unnecessary liver resection. Herein, we reported that two male cases with FNH, who initially presented with persistent abdominal discomfort, were misdiagnosed with hepatocellular adenoma (HCA) and hepatocellular carcinoma (HCC) on contrast-enhanced magnetic resonance imaging and computed tomography scans, respectively. After surgery, a histological diagnosis of FNH was finally established. In this paper, we also reviewed the knowledge regarding diagnosis and differential diagnosis of FNH on imaging examinations, which are helpful for avoiding misdiagnoses and guiding clinical interventions.

KEYWORDS: Focal nodular hyperplasia, hepatobiliary contrast agents, contrast-enhanced ultrasound, hepatocellular adenoma, hepatocellular carcinoma

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