Drug Discov Ther. 2021;15(6):341-343. (DOI: 10.5582/ddt.2021.01095)

Entomophthoramycosis: An unusual cause of facial disfigurement

Mondal A, Basu A, Mandal M, Mallik A, Modak DC, Pal D, Majumder D, Guha SK


Entomophthoramycosis is a rare fungal infection of nose, paranasal sinuses and subcutaneous tissues found in tropical and subtropical region. From India very few cases have been reported. Here we report a case of Entomophthoramycosis due to Conidiobolus coronatus from the eastern India who presented with slowly growing rhinofacial swelling and right sided nasal obstruction due to intranasal mass. The case was diagnosed by typical histopathological findings of broad aseptate hyphae with surrounding eosinophilic granular material (Splendore Hoeppli phenomenon) on microscopy of nasal biopsy material and confirmed by PCR assay of DNA and sequencing from biopsy tissue. Treatment with saturated solution of potassium iodide and itraconazole was successful and clinical cure was attained in 8 months.

KEYWORDS: Entomophthoramycosis, Conidiobolus coronatus, Splendore Hoeppli phenomenon

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