Drug Discov Ther. 2022;16(2):102-104. (DOI: 10.5582/ddt.2021.01015)

Pulse corticosteroids for the management of extensive CNS tuberculosis presenting with acute-onset quadriparesis

Arora U, Garg P, Raut SK, Vibha D, Baitha U, Kumar A, Jorwal P, Soneja M, Biswas A


Myelopathy in central nervous system tuberculosis is notorious for poor outcomes, determined by the severity of inflammation and cord level involved. Acute-onset quadriplegia or paraplegia in these cases represents a neuro-emergency. We report a young female with disseminated tuberculosis who presented with acute onset flaccid quadriparesis with loss of bladder and bowel function. Imaging helped identify the extensive involvement of the neuraxis. We propose that, in addition to anti-tubercular therapy, high-dose corticosteroids such as pulse methylprednisolone may result in a meaningful improvement and show greater rapidity of response in cases of severe central nervous system inflammation such as arachnoiditis or myelopathy.

KEYWORDS: Tuberculosis, meningitis, myelopathy, immunosuppression

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