Drug Discov Ther. 2023;17(2):87-94. (DOI: 10.5582/ddt.2022.01109)
Advances in understanding the effect and mechanism of dehydroepiandrosterone on diminished ovarian reserve
Wang J, Pan XY, Zhou J, Li X, Sun Y, Wang L
Diminished ovarian reserve (DOR) refers to the decline in fertility caused by the loss of normal ovarian function. DOR is associated with adverse reactions to ovarian stimulation during in vitro fertilization and embryo transfer (IVF-ET), increasing cycle cancellation rates and reducing pregnancy rates. Although it is well known that dehydroepiandrosterone (DHEA) can be used as a dietary supplement for age-related diseases, its potential has gradually been shown for many diseases. In this review, we focus on the effects of DHEA on DOR, briefly analysing its clinical benefits and limitations and describing the mechanism of function and the clinical trials conducted. Therefore, we summarize the mechanisms and indications of DHEA for DOR.