Drug Discov Ther. 2023;17(3):177-182. (DOI: 10.5582/ddt.2023.01022)

Autoimmune hepatitis following COVID-19 vaccination: Clinical characteristics of 35 reported cases

Wang MR, Qi Juan, Liu YJ


The coronavirus disease 2019 (COVID-19) vaccines have been shown to be effective in protecting people from severe disease progression, hospitalisation and death. However, a wide range of side effects have been reported worldwide. New onset or flare-up of autoimmune hepatitis (AIH) is an extremely rare adverse event following COVID-19 vaccination, with the majority of cases presenting with mild symptoms. Unfortunately, there have been cases of fatal complications. In this mini-review, we have summarised the clinical characteristics of a total of 35 currently reported cases of AIH after COVID-19 vaccination and suggest that patients with autoimmune diseases may be at higher risk of developing AIH after vaccination.

KEYWORDS: COVID-19, vaccines, adverse events, autoimmune hepatitis

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