Drug Discov Ther. 2023;17(3):214-216. (DOI: 10.5582/ddt.2022.01121)

Factors contributing to carboplatin blockade and interruption in its route of administration in paclitaxel-carboplatin therapy

Inoue M, Nakadate K, Oosaki M, Shirota M, Yasu T


The interruption of anticancer infusion processes in patients undergoing chemotherapy may affect their quality of life and the efficacy and safety of the therapy. We experienced several interruptions of carboplatin infusion in multiple patients receiving paclitaxel-carboplatin combination therapy. Therefore, we investigated the causes of these interruptions. The filter and catheter surfaces were evaluated by scanning electron microscopy. Moreover, using a texture analyzer, the mechanical strengths of catheter-attached syringes were compared pre- and post-administration. We observed that the syringe pushing force requirement was higher following dripping failure. However, precipitates were not evident on the filter surfaces, regardless of the dripping failure route. In this case, some of the drug adhered to the catheters' surfaces and interrupted the carboplatin titration. Consequently, in patients receiving combination therapy with paclitaxel and carboplatin, and experiencing interruptions in carboplatin infusion, attention should be paid to the catheter.

KEYWORDS: adsorption, catheters, scanning electron microscopy, syringe pushing force

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