Drug Discov Ther. 2010;4(6):392-398.
Synthesis, characterization, and anthelmintic activity of novel 6,7,8,9-tetrahydro-5H-5-phenyl-2-benzylidine-3-substituted hydrazino thiazolo (2,3-b) quinazoline derivatives and analogues.
Selvam TP, Kumar PV
SUMMARY
Several novel 6,7,8,9-tetrahydro-5H-5-phenyl-2-benzylidine-3-substituted hydrazine thiazolo (2,3-b) quinazoline derivatives were synthesized and evaluated for their anthelmintic activity in a passive avoidance test. Chemical structures of all of the newly synthesized compounds were confirmed by infrared spectroscopy, 1H-nuclear magnetic resonance, mass spectroscopy, and elemental analyses. Out of 15 compounds, only 6e and 6o had good anthelmintic activity. Experimental data led to the conclusion that the synthesized compounds have anthelmintic activity.
KEYWORDS: Thiazolo quinazoline, thiazolo quinazoline phenyl hydrazone, aromatic aldehyde substitution, benzylidine thiazolo quinazoline phenyl hydrazone, anthelmintic activity
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