Drug Discov Ther. 2012;6(5):238-241. (DOI: 10.5582/ddt.2012.v6.5.238)

A new boronic acid-based fluorescent sensor for L-dihydroxyphenylalanine.

Wu ZY, Yang XY, Xu WF, Wang BH, Fang H


Catecholamines, such as dopamine and L-dihydroxyphenylalanine (L-DOPA), are associated with different physiological functions and diseases. In our recent studies, a novel water-soluble boronic acid compound 3c was identified as a selective fluorescent sensor for L-DOPA. This compound not only has the ability to interact with dopamine and catechol, but also has no fluorescence intensity change for L-DOPA precursors in vivo, such as L-tyrosine.

KEYWORDS: Boronic acid, fluorescent chemosensor, L-DOPA, dopamine

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