Drug Discov Ther. 2013;7(3):101-104. (DOI: 10.5582/ddt.2013.v7.3.101)

A new phenoxazine derivative isolated from marine sediment actinomycetes, Nocardiopsis sp. 236.

Lu CH, Li YY, Wang HX, Wang BM, Shen YM


During screening of marine actinomycetes for anti-mycobacterial activity, a new phenoxazine derivative (1) was isolated, along with 6-phenazinediol (2), 6-methoxy-1-phenazinol (3), nocardamin (4), and 3-pyridinecarboxylic acid (5), from a culture of Nocardiopsis sp. 236 collected from the west Pacific. The chemical structure of 1 was established on the basis of 1D-, 2D-NMR, and HRQ-TOF MS data. All compounds were evaluated for their anti-mycobacterial activity in vitro, and only compounds 2 and 3 exhibited weak activity.

KEYWORDS: Nocardiopsis sp., phenazine, nocardamin, pyridine carboxylic acid

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