Drug Discov Ther. 2007;1(1):73-77.

Modification of 15-akylidene andrographolide derivatives as alpha-glucosidase inhibitor.

Xu HW, Liu GZ, Dai GF, Wu CL, Liu HM


15-Alkylidene andrographolide derivatives were specific alpha-glucosidase inhibitors. Semi-synthetic studies of these derivatives led to new alpha-glucosidase inhibitors. Their alpha-glucosidase inhibitory activity was evaluated. Bioactivity results indicated that most of the derivatives were excellent alpha-glucosidase inhibitors. Among them, 6c displayed the best alpha-glucosidase inhibitory bioactivity with an IC50 value of 8.3 mM.

KEYWORDS: Synthesis, andrographolide derivative, alpha-glucosidase inhibitor

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